Ceramide 1-phosphate transport

Across TCGA patient cohorts, RNA activity of the Ceramide 1-phosphate transport pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CERT1_S377, SCRIB_S1300, and SH3BP2_S444, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ceramide 1-phosphate transport activity versus CERT1_S377 in HNSC (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CERT1_S377 →	+0.430	+0.144	<.001	<.001	3	4
LSCC	SCRIB_S1300 →	+0.932	+0.376	<.001	<.001	3	2
BRCA	SH3BP2_S444 →	+0.708	+0.417	<.001	.001	3	2
GBM	SLX4IP →	-0.525	-0.473	.003	<.001	2	3
GBM	SNRK_S495 →	-0.766	-0.468	<.001	<.001	3	2
GBM	SUGP1_S409 →	+0.590	+0.190	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902389 vs CERT1_S377 — HNSC

Explore this scatter interactively →