Ceramide 1-phosphate transport

Across TCGA cell cohorts, RNA activity of the Ceramide 1-phosphate transport pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APPL1, PTN, and RAB13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, APPL1 grouped by Ceramide 1-phosphate transport-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	APPL1 →	+1.089	+1.753	.008	.001	3	4
CNS	PTN →	+6.088	+1.857	<.001	<.001	3	4
CNS	RAB13 →	+2.410	+1.857	.005	<.001	3	4
CNS	PRKCA →	+4.240	+1.857	.001	<.001	3	4
CNS	MYLK →	+5.001	+1.857	.002	<.001	3	4
CNS	STX7 →	+2.604	+1.857	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

APPL1 by Ceramide 1-phosphate transport activity — BLOOD_Lymphoma

Explore this box plot interactively →