Ceramide 1-phosphate transport

Across TCGA cell cohorts, RNA activity of the Ceramide 1-phosphate transport pathway is significantly associated with the drug response of multiple features, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are alpha-lipoic acid, Bosutinib, and Dasatinib, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, alpha-lipoic acid grouped by Ceramide 1-phosphate transport-low versus -high activity in BLOOD_Leukemia.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	alpha-lipoic acid →	+0.300	+0.061	.011	.036	2	2
BLOOD_Leukemia	Bosutinib →	+1.765	+0.061	.027	.036	1	2
BLOOD_Leukemia	Dasatinib →	+3.660	+0.061	.002	.036	2	1
BLOOD_Leukemia	EPZ5676 →	+0.168	+0.061	.004	.036	2	1
BLOOD_Leukemia	THR-101 →	+0.253	+0.061	<.001	.036	2	1
BLOOD_Leukemia	TWS119 →	+0.976	+0.061	.002	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

alpha-lipoic acid by Ceramide 1-phosphate transport activity — BLOOD_Leukemia

Explore this box plot interactively →