Positive regulation of apoptotic process involved in morphogenesis

Across TCGA patient cohorts, RNA activity of the Positive regulation of apoptotic process involved in morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KYNU, GHRL, and PPP1R11P2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of apoptotic process involved in morphogenesis activity versus KYNU in PDAC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	KYNU →	+0.547	+0.440	.003	.008	3	3
COAD	GHRL →	+0.293	+0.256	<.001	.002	3	3
COAD	PPP1R11P2 →	+0.202	+0.224	.008	.007	2	4
CCRCC	MIR4786 →	+0.940	+0.649	.001	<.001	3	3
COAD	MIR3198-1 →	+0.595	+0.212	.002	.005	3	3
COAD	MIR4768 →	+1.216	+0.217	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902339 vs KYNU — PDAC

Explore this scatter interactively →