Positive regulation of sodium ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Positive regulation of sodium ion transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TESC, TRMT5, and AQR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of sodium ion transmembrane transport activity versus TESC in LUAD (Pearson r = 0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TESC →	+0.773	+0.060	<.001	<.001	3	6
GBM	TRMT5 →	-0.269	-0.051	<.001	<.001	3	5
GBM	AQR →	-0.194	-0.052	.001	.001	3	5
GBM	RFC1_T506 →	-0.769	-0.070	<.001	<.001	3	5
GBM	MCM7 →	-0.449	-0.055	.008	.002	3	5
LSCC	XPO5 →	-0.594	-0.053	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902307 vs TESC — LUAD

Explore this scatter interactively →