Cell cycle DNA replication initiation

Across TCGA cell cohorts, RNA activity of the Cell cycle DNA replication initiation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MALSU1, OR2J3, and DBNDD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MALSU1 grouped by Cell cycle DNA replication initiation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MALSU1 →	-0.628	-0.097	.006	.006	3	5
LUNG_SCLC	OR2J3 →	-0.022	-0.140	.006	<.001	3	4
SOFT_TISSUE	DBNDD2 →	+2.038	+0.133	.001	<.001	3	4
BLOOD_Leukemia	NFATC4 →	-3.060	-0.135	<.001	.001	3	3
BLOOD_Leukemia	DOK4 →	-1.798	-0.149	.007	.004	3	3
BLOOD_Leukemia	PPA2 →	+0.806	+0.162	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MALSU1 by Cell cycle DNA replication initiation activity — CNS

Explore this box plot interactively →