Regulation of chromatin organization

Across TCGA cell cohorts, RNA activity of the Regulation of chromatin organization pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ASB7, TOP2A, and MKI67, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of chromatin organization activity versus ASB7 in LUNG_SCLC (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ASB7 →	+1.816	+0.322	<.001	<.001	3	13
BREAST	TOP2A →	+1.209	+0.222	.009	.001	3	11
BREAST	MKI67 →	+1.663	+0.285	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	SMARCA5 →	+0.684	+0.243	<.001	.001	3	11
BONE	PNN →	+0.628	+0.335	<.001	<.001	3	10
SOFT_TISSUE	BAZ1A →	+1.194	+0.214	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902275 vs ASB7 — LUNG_SCLC

Explore this scatter interactively →