Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator

Across TCGA patient cohorts, RNA activity of the Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PVT1, LMO1, and C19orf57, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator activity versus PVT1 in BRCA (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PVT1 →	-0.407	-0.089	.009	.002	3	4
UCEC	LMO1 →	-0.572	-0.259	.002	<.001	3	4
CCRCC	C19orf57 →	-0.281	-0.131	.002	.001	3	3
BRCA	KAT2A →	-0.672	-0.114	.001	.006	3	3
BRCA	NAT9 →	-0.736	-0.178	<.001	<.001	3	3
LSCC	VPS25 →	-0.470	-0.147	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902255 vs PVT1 — BRCA

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