Regulation of intrinsic apoptotic signaling pathway by p53 class mediator

Across TCGA patient cohorts, RNA activity of the Regulation of intrinsic apoptotic signaling pathway by p53 class mediator pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDN1, ACADSB, and ILDR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of intrinsic apoptotic signaling pathway by p53 class mediator activity versus EDN1 in UCEC (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EDN1 →	-0.916	-0.173	.007	.009	3	5
HNSC	ACADSB →	+0.502	+0.172	.007	.001	3	4
HNSC	ILDR1 →	+0.577	+0.135	.004	.002	3	3
HNSC	CAMK2G →	+0.367	+0.215	.003	<.001	3	3
GBM	ICAM5 →	-0.714	-0.136	.007	.008	3	3
UCEC	CCRL2 →	-0.809	-0.245	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902253 vs EDN1 — UCEC

Explore this scatter interactively →