Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CEP170, COL3A1, and EPB41L5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway activity versus CEP170 in COAD (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CEP170 →	+0.254	+0.042	.008	.002	2	7
CCRCC	COL3A1 →	+0.679	+0.052	.006	.001	3	6
COAD	EPB41L5 →	-0.235	-0.031	.009	.004	3	6
CCRCC	CTNND1 →	-0.283	-0.070	<.001	<.001	3	5
LSCC	FRMD4A_S335 →	+0.470	+0.045	.001	.001	3	5
UCEC	MAP1B_S1154 →	+1.130	+0.074	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902237 vs CEP170 — COAD

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