Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRWD1-AS1, TMEM167A, and ANXA4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway activity versus BRWD1-AS1 in CCRCC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	BRWD1-AS1 →	-0.366	-0.627	<.001	<.001	3	3
CCRCC	TMEM167A →	-0.352	-0.654	.005	<.001	3	3
CCRCC	ANXA4 →	-0.511	-0.651	.008	.004	3	3
GBM	MIR378A →	-0.977	-0.376	<.001	.005	3	3
GBM	COL5A3 →	-0.612	-0.256	.008	.009	3	3
UCEC	NPAS3 →	-1.057	-0.758	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902237 vs BRWD1-AS1 — CCRCC

Explore this scatter interactively →