Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGB3BP, DCLRE1C, and KLHL21, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITGB3BP grouped by Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ITGB3BP →	+0.791	+1.076	.006	.009	3	4
URINARY_TRACT	DCLRE1C →	-1.033	-2.199	.006	<.001	3	4
BLOOD_Leukemia	KLHL21 →	-1.068	-1.204	.001	.002	3	4
KIDNEY	TRIM22 →	-3.188	-1.300	<.001	<.001	3	4
CNS	ARFGEF2 →	-0.654	-1.042	<.001	<.001	3	4
CNS	ATP10D →	-1.124	-1.023	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITGB3BP by Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway activity — STOMACH

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