Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD69, XBP1, and CA9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD69 grouped by Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CD69 →	+0.230	+0.105	.001	.001	3	5
SOFT_TISSUE	XBP1 →	+0.171	+0.139	.005	<.001	3	4
LIVER	CA9 →	+0.205	+0.104	<.001	.001	3	4
LIVER	CCDC91 →	-0.263	-0.130	.001	.001	3	4
LIVER	SLC9A8 →	+0.165	+0.121	.007	.002	3	4
LIVER	OR5M1 →	+0.278	+0.128	.005	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD69 by Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway activity — SOFT_TISSUE

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