Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDN1, DCAF10, and RAB9B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway activity versus EDN1 in LARGE_INTESTINE (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EDN1 →	+2.425	+0.499	<.001	.001	3	3
BLOOD_Leukemia	DCAF10 →	+1.016	+0.488	<.001	<.001	3	3
BLOOD_Leukemia	RAB9B →	+1.164	+0.370	<.001	<.001	3	3
BLOOD_Leukemia	OCIAD2 →	+2.969	+0.294	.002	.001	3	3
BLOOD_Leukemia	ZNF41 →	+0.560	+0.275	<.001	.005	3	3
BLOOD_Leukemia	ARMC12 →	+1.175	+0.346	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902237 vs EDN1 — LARGE_INTESTINE

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