Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF113B, CSF3R, and ELP6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway activity versus RNF113B in LSCC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RNF113B →	-0.405	-0.189	.004	.006	3	6
OV	CSF3R →	+1.283	+0.208	<.001	<.001	3	5
LSCC	ELP6 →	-0.387	-0.259	<.001	<.001	3	5
OV	RRM1 →	-0.547	-0.156	.001	<.001	3	5
LSCC	RAB15 →	-0.662	-0.292	<.001	<.001	3	5
GBM	BEND3 →	-0.535	-0.169	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902235 vs RNF113B — LSCC

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