Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LDHAL6A, YPEL1, and TTC9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LDHAL6A grouped by Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LDHAL6A →	-0.036	-0.297	.008	.003	3	4
OVARY	YPEL1 →	+0.612	+0.685	.003	.001	3	4
LUNG_SCLC	TTC9 →	+1.639	+0.325	.004	.008	1	5
BREAST	TMEM38A →	+1.123	+0.856	.004	<.001	3	3
LUNG_NSCLC_LUSC	HSF4 →	+1.138	+0.245	.009	.008	3	3
LUNG_NSCLC_LUSC	ZBED6CL →	+1.733	+0.267	.005	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LDHAL6A by Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway activity — LUNG_NSCLC_LUAD

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