Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMSB15B, HECTD4, and NOP9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway activity versus TMSB15B in BLOOD_Leukemia (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMSB15B →	-2.546	-0.209	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	HECTD4 →	-1.335	-0.179	<.001	.001	3	5
CNS	NOP9 →	-0.585	-0.159	.002	.001	3	5
PANCREAS	RPLP0 →	-0.741	-0.180	<.001	.001	3	5
SKIN	DRD4 →	+0.234	+0.222	<.001	<.001	3	5
KIDNEY	ZBTB17 →	+0.702	+0.168	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902235 vs TMSB15B — BLOOD_Leukemia

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