Ketone body metabolic process

Across TCGA patient cohorts, RNA activity of the Ketone body metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AACS, CLUH, and TIMP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ketone body metabolic process activity versus AACS in HNSC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AACS →	+0.446	+0.096	<.001	<.001	3	8
COAD	CLUH →	+0.348	+0.053	<.001	<.001	3	7
PDAC	TIMP2 →	-0.331	-0.041	<.001	.007	3	7
GBM	SGCD →	-0.641	-0.068	<.001	<.001	3	6
PDAC	AFAP1_S548 →	-0.617	-0.070	<.001	<.001	3	6
OV	LGALS1_S30 →	-0.815	-0.042	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902224 vs AACS — HNSC

Explore this scatter interactively →