Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

Across TCGA patient cohorts, RNA activity of the Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PELATON, LEPROTL1, and LGALS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress activity versus PELATON in PDAC (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PELATON →	+0.496	+0.574	.001	.003	3	5
COAD	LEPROTL1 →	+0.423	+0.586	.001	.003	3	4
BRCA	LGALS1 →	+0.872	+0.712	.004	.003	3	4
BRCA	CAB39L →	-0.859	-0.772	<.001	<.001	3	4
BRCA	ANP32E →	+0.899	+0.788	.002	<.001	3	4
LSCC	CRNKL1 →	-0.392	-0.157	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902219 vs PELATON — PDAC

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