Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FDXR, STX11, and EIF4B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FDXR grouped by Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FDXR →	+1.512	+0.276	.005	.006	3	5
LIVER	STX11 →	-2.546	-0.532	<.001	.005	3	4
LIVER	EIF4B →	+0.653	+0.359	.007	.008	2	5
STOMACH	CASP1 →	-2.830	-0.354	.001	.002	3	4
OVARY	ESYT2 →	-0.796	-0.461	<.001	.002	3	4
BLOOD_Myeloma	SERPINE2 →	-3.382	-0.513	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FDXR by Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway activity — STOMACH

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