Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHRNB2, PSMD7, and EZH1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of oxidative stress-induced intrinsic apoptotic signaling pathway activity versus CHRNB2 in LSCC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CHRNB2 →	-0.475	-0.147	.003	.006	3	3
OV	PSMD7 →	+0.424	+0.102	.009	.008	3	3
OV	EZH1 →	-0.573	-0.096	.005	.008	3	3
OV	TMOD4 →	-0.427	-0.086	<.001	.005	2	4
BRCA	IFT74-AS1 →	-0.272	-0.102	.001	.003	3	3
BRCA	ERVK9-11 →	-0.424	-0.113	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902175 vs CHRNB2 — LSCC

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