Cellular response to reactive nitrogen species

Across TCGA patient cohorts, RNA activity of the Cellular response to reactive nitrogen species pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL6A3, MRC2, and MAPK10-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to reactive nitrogen species activity versus COL6A3 in UCEC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COL6A3 →	+1.009	+0.201	<.001	<.001	3	4
UCEC	MRC2 →	+0.778	+0.159	.006	.003	3	4
UCEC	MAPK10-AS1 →	+0.742	+0.155	.001	.005	3	4
BRCA	PPFIBP1 →	+0.487	+0.166	.004	.001	3	3
UCEC	UST →	+1.022	+0.236	<.001	<.001	3	3
UCEC	HSPA12B →	+0.552	+0.152	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902170 vs COL6A3 — UCEC

Explore this scatter interactively →