Cellular response to reactive nitrogen species

Across TCGA cell cohorts, RNA activity of the Cellular response to reactive nitrogen species pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAXDC2, CRACD, and RHOC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAXDC2 grouped by Cellular response to reactive nitrogen species-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAXDC2 →	+1.444	+0.385	<.001	<.001	3	5
LARGE_INTESTINE	CRACD →	-0.902	-0.268	.006	.002	3	5
BLOOD_Lymphoma	RHOC →	+3.094	+0.513	.009	.004	3	4
BLOOD_Leukemia	STAT3 →	+1.322	+0.861	.003	.003	3	4
LARGE_INTESTINE	PHB2 →	-0.548	-0.440	.002	.006	3	4
BLOOD_Lymphoma	SRPRA →	+1.370	+0.513	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAXDC2 by Cellular response to reactive nitrogen species activity — LARGE_INTESTINE

Explore this box plot interactively →