Negative regulation of organelle assembly

Across TCGA patient cohorts, RNA activity of the Negative regulation of organelle assembly pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DCK, RIN1, and MAST4_S1523, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of organelle assembly activity versus DCK in BRCA (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DCK →	+0.346	+0.030	<.001	.003	3	5
LSCC	RIN1 →	-0.582	-0.032	.001	.008	3	5
LUAD	MAST4_S1523 →	-0.395	-0.025	.002	.006	3	5
LSCC	PRPF4B →	+0.233	+0.038	<.001	<.001	3	5
LSCC	WRNIP1 →	+0.330	+0.031	.001	.005	3	5
LSCC	SETDB1_S1066 →	+0.816	+0.049	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902116 vs DCK — BRCA

Explore this scatter interactively →