Regulation of organelle assembly

Across TCGA cell cohorts, RNA activity of the Regulation of organelle assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LSM3, TPM4, and MICA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of organelle assembly activity versus LSM3 in LUNG_NSCLC_LUAD (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LSM3 →	+0.571	+0.117	.005	.004	3	6
LIVER	TPM4 →	+1.752	+0.172	<.001	<.001	3	5
LUNG_NSCLC_LUAD	MICA →	+1.367	+0.174	<.001	<.001	3	5
SKIN	POC1A →	+0.574	+0.095	.002	.009	3	5
LIVER	PGM3 →	+1.497	+0.177	.009	.005	3	5
LIVER	VAMP5 →	+3.987	+0.172	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902115 vs LSM3 — LUNG_NSCLC_LUAD

Explore this scatter interactively →