Regulation of mitochondrial membrane permeability involved in apoptotic process

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial membrane permeability involved in apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PBXIP1, KIAA0319L, and FBXO16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial membrane permeability involved in apoptotic process activity versus PBXIP1 in LSCC (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PBXIP1 →	+0.412	+0.168	<.001	.003	3	5
PDAC	KIAA0319L →	+0.240	+0.138	.003	.002	3	4
BRCA	FBXO16 →	+0.503	+0.167	.002	.005	3	4
LUAD	ATP5IF1 →	+0.301	+0.173	.001	<.001	3	4
LUAD	TRMT11 →	+0.293	+0.144	.004	.007	3	4
GBM	ZBTB44-DT →	+0.268	+0.218	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902108 vs PBXIP1 — LSCC

Explore this scatter interactively →