Positive regulation of metaphase/anaphase transition of cell cycle

Across TCGA patient cohorts, RNA activity of the Positive regulation of metaphase/anaphase transition of cell cycle pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFC3, MTFR2, and PLK1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of metaphase/anaphase transition of cell cycle activity versus RFC3 in GBM (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RFC3 →	+0.642	+0.524	<.001	<.001	3	9
LSCC	MTFR2 →	+0.691	+0.780	<.001	<.001	3	9
BRCA	PLK1 →	+0.893	+1.042	<.001	<.001	3	8
BRCA	ORC6 →	+0.970	+1.000	<.001	<.001	3	8
GBM	TOP2A →	+1.315	+0.749	<.001	<.001	3	8
GBM	NUF2 →	+0.994	+0.635	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902101 vs RFC3 — GBM

Explore this scatter interactively →