Cellular response to salt

Across TCGA patient cohorts, RNA activity of the Cellular response to salt pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMNB1, P3H1, and DLST, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to salt activity versus LMNB1 in COAD (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LMNB1 →	-1.175	-0.321	<.001	.007	3	2
BRCA	P3H1 →	-1.508	-0.238	<.001	.004	3	2
COAD	DLST →	-0.588	-0.249	.002	<.001	3	2
COAD	XRCC3 →	-0.580	-0.208	.006	.005	3	2
COAD	PODXL →	-0.781	-0.215	.007	.003	3	2
COAD	SNORD100 →	-0.974	-0.230	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902075 vs LMNB1 — COAD

Explore this scatter interactively →