Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Across TCGA patient cohorts, RNA activity of the Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are APOC1, SERPING1, and RBM5_S78, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors activity versus APOC1 in OV (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	APOC1 →	+0.634	+0.040	<.001	.004	3	6
GBM	SERPING1 →	+0.488	+0.072	.004	<.001	2	6
OV	RBM5_S78 →	-0.547	-0.045	<.001	.001	3	5
OV	C8B →	+0.389	+0.040	.001	.004	2	6
PDAC	RAB3D →	-0.493	-0.047	<.001	.003	3	5
OV	FGA →	+0.732	+0.056	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902043 vs APOC1 — OV

Explore this scatter interactively →