Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Across TCGA patient cohorts, RNA activity of the Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIMC1, GIMAP8, and MGP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors activity versus SIMC1 in LSCC (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SIMC1 →	-0.461	-0.131	.002	<.001	3	5
GBM	GIMAP8 →	+0.856	+0.219	<.001	<.001	3	5
COAD	MGP →	+1.193	+0.209	.001	.001	3	5
HNSC	PLCB2 →	+0.514	+0.134	.001	<.001	3	5
PDAC	SLC9A9 →	+0.678	+0.189	<.001	<.001	3	5
PDAC	MS4A4E →	+0.738	+0.205	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902043 vs SIMC1 — LSCC

Explore this scatter interactively →