Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Across TCGA cell cohorts, RNA activity of the Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCL18, SLC24A4, and IL22RA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCL18 grouped by Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CCL18 →	-0.415	-1.839	.007	<.001	3	4
BONE	SLC24A4 →	-0.225	-0.339	<.001	.002	3	4
CNS	IL22RA2 →	-0.186	-0.154	.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	RHEB →	-0.356	-0.272	.009	.001	3	3
UPPER_AERODIGESTIVE_TRACT	DMRTC2 →	+0.102	+0.290	.005	.009	3	3
UPPER_AERODIGESTIVE_TRACT	CHRM1 →	-0.210	-0.265	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCL18 by Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors activity — BLOOD_Lymphoma

Explore this box plot interactively →