Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

Across TCGA cell cohorts, RNA activity of the Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOAT1, RTL8C, and TCEAL3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors activity versus SOAT1 in LARGE_INTESTINE (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SOAT1 →	+1.356	+0.235	.001	<.001	3	8
BLOOD_Leukemia	RTL8C →	+2.394	+0.262	<.001	<.001	3	7
LUNG_SCLC	TCEAL3 →	+1.753	+0.198	.001	.002	3	7
LUNG_NSCLC_LUAD	GNAI2 →	+0.702	+0.279	.003	.003	3	7
LUNG_SCLC	SLC23A2 →	+0.993	+0.254	.001	<.001	3	6
BREAST	PPP1R18 →	+1.700	+0.272	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902042 vs SOAT1 — LARGE_INTESTINE

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