Regulation of extrinsic apoptotic signaling pathway via death domain receptors

Across TCGA patient cohorts, RNA activity of the Regulation of extrinsic apoptotic signaling pathway via death domain receptors pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMP19, PELATON, and VIM, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of extrinsic apoptotic signaling pathway via death domain receptors activity versus MMP19 in GBM (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MMP19 →	+1.036	+0.195	.002	.002	3	6
COAD	PELATON →	+0.643	+0.747	<.001	<.001	3	6
COAD	VIM →	+0.951	+0.932	<.001	<.001	3	6
COAD	FCGR2A →	+0.657	+0.683	.002	<.001	3	5
COAD	ANKRD1 →	+0.393	+0.530	.005	.002	3	5
COAD	SERPING1 →	+1.211	+0.829	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902041 vs MMP19 — GBM

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