Regulation of extrinsic apoptotic signaling pathway via death domain receptors

Across TCGA cell cohorts, RNA activity of the Regulation of extrinsic apoptotic signaling pathway via death domain receptors pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR176, CD59, and ABL2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of extrinsic apoptotic signaling pathway via death domain receptors activity versus GPR176 in SOFT_TISSUE (Pearson r = 0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GPR176 →	+3.807	+0.532	.001	<.001	3	10
SOFT_TISSUE	CD59 →	+3.540	+0.459	<.001	<.001	3	9
LUNG_NSCLC_LUSC	ABL2 →	+2.018	+0.557	.004	.005	2	9
BLOOD_Leukemia	HOMER3 →	+3.022	+0.189	<.001	.007	3	8
BLOOD_Leukemia	ARPC2 →	+0.831	+0.277	.002	<.001	3	7
BONE	MT2A →	+3.962	+0.252	.001	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902041 vs GPR176 — SOFT_TISSUE

Explore this scatter interactively →