Negative regulation of hematopoietic stem cell differentiation

Across TCGA patient cohorts, RNA activity of the Negative regulation of hematopoietic stem cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFP36, FOSB, and MMP19, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of hematopoietic stem cell differentiation activity versus ZFP36 in LUAD (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ZFP36 →	+0.686	+0.648	<.001	<.001	3	5
PDAC	FOSB →	+0.696	+0.402	.008	.009	3	5
GBM	MMP19 →	+1.294	+0.552	<.001	.001	3	4
GBM	MSC →	+0.613	+0.602	.004	<.001	3	4
BRCA	NR4A3 →	+0.629	+0.482	.002	.007	3	4
LUAD	IL1RL1 →	+0.908	+0.573	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902037 vs ZFP36 — LUAD

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