Negative regulation of hematopoietic stem cell differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of hematopoietic stem cell differentiation pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Negative regulation of hematopoietic stem cell differentiation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and LAML, show the opposite pattern, with higher activity associated with better survival.

LGG, SKCM, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.665	0.790	<.001	30	view →
SKCM	OS	Tertile	All	0.386	0.253	.003	28	view →
KIRC	DFS	Tertile	III,IV	0.348	0.595	.006	27	view →
LAML	DFS	Tertile	All	0.468	0.231	.009	22	view →
UVM	DFS	Tertile	III,IV	0.275	0.686	.011	17	view →
ACC	OS	Quartile	All	0.244	0.690	.007	16	view →
KICH	DFS	Quartile	All	1.000	0.673	.015	14	view →
THYM	OS	Median	All	0.906	1.000	.002	14	view →
READ	OS	Median	III,IV	0.693	0.391	.006	13	view →
GBM	DFS	Tertile	All	0.170	0.399	.016	12	view →
BRCA	DFS	Median	II,III,IV	0.959	0.926	.013	12	view →
LUSC	OS	Tertile	II,III,IV	0.804	0.623	.018	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:1902037–LGG (DFS)

Open the LGG breakdown →