Positive regulation of hematopoietic stem cell proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of hematopoietic stem cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STUB1_S19, KIF13A, and ARHGEF12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of hematopoietic stem cell proliferation activity versus STUB1_S19 in PDAC (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	STUB1_S19 →	-0.341	-0.048	.002	.001	3	6
OV	KIF13A →	+0.316	+0.053	.005	.005	3	6
UCEC	ARHGEF12 →	+0.173	+0.111	<.001	<.001	3	5
OV	WNT5A →	+0.797	+0.043	<.001	.008	3	5
LUAD	TRIM2 →	+0.553	+0.079	<.001	<.001	3	5
OV	RAI14_S667 →	+0.679	+0.054	.006	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902035 vs STUB1_S19 — PDAC

Explore this scatter interactively →