Regulation of NADP metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of NADP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MDM2, FDXR, and CES2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MDM2 grouped by Regulation of NADP metabolic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MDM2 →	-2.036	-1.496	<.001	<.001	3	5
SKIN	FDXR →	-1.715	-1.563	<.001	<.001	3	4
BLOOD_Myeloma	CES2 →	-1.214	-0.287	.007	<.001	2	5
SOFT_TISSUE	BNIP3L →	+1.338	+1.285	.007	.006	3	4
BLOOD_Lymphoma	STAT5A →	+3.884	+0.326	.006	.005	3	4
SOFT_TISSUE	ZNF22 →	+3.674	+1.628	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MDM2 by Regulation of NADP metabolic process activity — SKIN

Explore this box plot interactively →