Regulation of cilium-dependent cell motility

Across TCGA patient cohorts, RNA activity of the Regulation of cilium-dependent cell motility pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DSTN, EVI2B, and JPT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cilium-dependent cell motility activity versus DSTN in COAD (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DSTN →	+0.324	+0.030	.006	.001	3	5
CCRCC	EVI2B →	-0.402	-0.049	.002	<.001	3	5
CCRCC	JPT2 →	+0.216	+0.039	.001	.002	3	5
OV	ARHGAP45 →	-0.435	-0.058	.003	.003	3	5
CCRCC	PTPN7 →	-0.351	-0.042	.006	<.001	3	5
LUAD	RABGAP1L →	-0.137	-0.026	.002	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902019 vs DSTN — COAD

Explore this scatter interactively →