Regulation of cilium-dependent cell motility

Across TCGA patient cohorts, RNA activity of the Regulation of cilium-dependent cell motility pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DOCK8, IRAG2, and RNF180, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cilium-dependent cell motility activity versus DOCK8 in HNSC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DOCK8 →	+0.768	+0.672	<.001	<.001	3	3
HNSC	IRAG2 →	+0.701	+0.722	.002	<.001	3	3
LSCC	RNF180 →	+0.541	+0.247	.003	.006	3	3
LSCC	LINC02056 →	+0.241	+0.305	.006	.002	3	3
LUAD	SMOC1 →	+0.957	+0.268	.002	.004	3	2
UCEC	RNA5SP493 →	-0.857	-0.723	.007	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902019 vs DOCK8 — HNSC

Explore this scatter interactively →