Regulation of cilium-dependent cell motility

Across TCGA cell cohorts, RNA activity of the Regulation of cilium-dependent cell motility pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM70, ZWINT, and DDAH2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM70 grouped by Regulation of cilium-dependent cell motility-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TMEM70 →	+0.852	+1.835	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	ZWINT →	-1.515	-0.947	.007	.009	3	4
UPPER_AERODIGESTIVE_TRACT	DDAH2 →	-1.384	-1.309	.002	.003	2	5
SOFT_TISSUE	RDH5 →	-0.978	-1.522	.002	<.001	3	4
SKIN	FOSB →	+1.991	+0.907	.004	.005	2	4
SKIN	EIF2A →	-0.539	-1.028	.006	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM70 by Regulation of cilium-dependent cell motility activity — BLOOD_Lymphoma

Explore this box plot interactively →