Negative regulation of meiotic cell cycle phase transition

Across TCGA patient cohorts, RNA activity of the Negative regulation of meiotic cell cycle phase transition pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOPBP1, RRM2, and WDR43_S431, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of meiotic cell cycle phase transition activity versus TOPBP1 in LSCC (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TOPBP1 →	+0.339	+0.367	<.001	<.001	3	6
LUAD	RRM2 →	+0.897	+0.284	<.001	<.001	3	6
HNSC	WDR43_S431 →	+1.205	+0.333	<.001	<.001	3	6
LUAD	CDC6_S54 →	+1.667	+0.503	<.001	<.001	3	6
COAD	CKAP2 →	+1.605	+0.566	<.001	<.001	3	6
LUAD	COIL_T303 →	+1.389	+0.380	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901994 vs TOPBP1 — LSCC

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