Positive regulation of mitotic cell cycle phase transition

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitotic cell cycle phase transition pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DYNC2H1, WDR86, and ARL6, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DYNC2H1 grouped by Positive regulation of mitotic cell cycle phase transition-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DYNC2H1 →	+0.300	+0.146	<.001	<.001	3	8
BREAST	WDR86 →	+0.198	+0.126	.003	.009	3	8
LUNG_NSCLC_LUSC	ARL6 →	+0.223	+0.144	.002	.005	3	7
STOMACH	SERPINE2 →	+0.240	+0.154	.003	.008	3	7
LUNG_SCLC	ZNF607 →	+0.313	+0.132	.007	.008	3	6
LUNG_SCLC	MAP3K3 →	+0.252	+0.156	<.001	.004	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DYNC2H1 by Positive regulation of mitotic cell cycle phase transition activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →