Negative regulation of mitotic cell cycle phase transition

Across TCGA cell cohorts, RNA activity of the Negative regulation of mitotic cell cycle phase transition pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAA38, CSKMT, and KIF11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NAA38 grouped by Negative regulation of mitotic cell cycle phase transition-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NAA38 →	-0.921	-0.130	<.001	.002	3	5
STOMACH	CSKMT →	-1.039	-0.145	.004	.007	3	5
PANCREAS	KIF11 →	-1.011	-0.145	.001	.001	3	5
BLOOD_Lymphoma	CROCC →	+2.025	+0.350	.004	.001	3	4
URINARY_TRACT	TOP2A →	-0.994	-0.267	.007	.006	3	4
STOMACH	PBK →	-1.072	-0.107	.003	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NAA38 by Negative regulation of mitotic cell cycle phase transition activity — STOMACH

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