Positive regulation of protein acetylation

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein acetylation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HDAC2, SMC1A, and WDR70, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein acetylation activity versus HDAC2 in LSCC (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HDAC2 →	+0.259	+0.038	.002	.001	3	6
HNSC	SMC1A →	+0.141	+0.043	.002	.005	3	5
HNSC	WDR70 →	+0.241	+0.066	<.001	.001	3	5
HNSC	WRNIP1 →	+0.204	+0.043	.002	.005	3	5
LSCC	ZMYM4 →	+0.249	+0.039	.005	.005	3	5
BRCA	ILKAP →	+0.261	+0.034	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901985 vs HDAC2 — LSCC

Explore this scatter interactively →