Negative regulation of protein acetylation

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein acetylation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ECT2_T359, BAZ1B_S349, and TOP2A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein acetylation activity versus ECT2_T359 in PDAC (Pearson r = -0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ECT2_T359 →	+1.240	+0.078	<.001	<.001	3	8
PDAC	BAZ1B_S349 →	+0.902	+0.071	<.001	<.001	3	7
LUAD	TOP2A →	+0.874	+0.074	<.001	<.001	3	7
PDAC	TOP2A_S1106 →	+1.085	+0.063	<.001	<.001	3	7
PDAC	TOP2A_S1213 →	+0.824	+0.079	<.001	<.001	3	7
LUAD	BRCA1_S114 →	+0.832	+0.058	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901984 vs ECT2_T359 — PDAC

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