Negative regulation of protein acetylation

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein acetylation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YPEL1, PDLIM2, and DNAJC9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein acetylation activity versus YPEL1 in HNSC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	YPEL1 →	+0.600	+0.215	<.001	<.001	3	5
PDAC	PDLIM2 →	-0.275	-0.169	<.001	<.001	3	5
BRCA	DNAJC9 →	+0.540	+0.152	<.001	.001	3	5
BRCA	LMNB1 →	+0.664	+0.160	.001	<.001	3	4
OV	COL3A1 →	-1.760	-0.209	<.001	.001	3	4
BRCA	FIBIN →	-0.919	-0.115	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901984 vs YPEL1 — HNSC

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