Negative regulation of cell cycle checkpoint

Across TCGA cell cohorts, RNA activity of the Negative regulation of cell cycle checkpoint pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H4C14, TESPA1, and FMNL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, H4C14 grouped by Negative regulation of cell cycle checkpoint-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	H4C14 →	+2.477	+0.419	<.001	.006	3	5
OVARY	TESPA1 →	-0.044	-0.200	.008	<.001	3	4
LUNG_NSCLC_LUAD	FMNL3 →	-0.860	-0.166	<.001	.001	3	4
LUNG_NSCLC_LUSC	TRPV3 →	+1.015	+0.298	.005	<.001	3	4
LUNG_NSCLC_LUSC	FBXW11 →	-1.043	-0.363	.003	.001	3	4
LIVER	RAB34 →	-3.312	-0.183	.008	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

H4C14 by Negative regulation of cell cycle checkpoint activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →