Positive regulation of mitotic sister chromatid separation

Across TCGA cell cohorts, RNA activity of the Positive regulation of mitotic sister chromatid separation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SKA3, FOXM1, and ESPL1, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of mitotic sister chromatid separation activity versus SKA3 in BONE (Pearson r = 0.89).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SKA3 →	+1.603	+0.178	<.001	.002	3	20
URINARY_TRACT	FOXM1 →	+1.748	+0.164	<.001	<.001	3	20
SOFT_TISSUE	ESPL1 →	+1.597	+0.186	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	FANCI →	+1.727	+0.122	<.001	.005	3	20
OESOPHAGUS	MAD2L1 →	+1.528	+0.197	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	KIFC1 →	+1.528	+0.177	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1901970 vs SKA3 — BONE

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