Regulation of relaxation of cardiac muscle

Across TCGA cell cohorts, RNA activity of the Regulation of relaxation of cardiac muscle pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF721, CHD1, and BROX, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF721 grouped by Regulation of relaxation of cardiac muscle-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ZNF721 →	+1.351	+1.408	.006	<.001	3	4
BONE	CHD1 →	-0.743	-1.538	.003	.002	3	3
PANCREAS	BROX →	-0.446	-1.014	.008	.002	3	3
PANCREAS	TMEM150A →	-0.636	-1.074	.007	.007	3	3
PANCREAS	GALNT11 →	-0.764	-1.014	.004	.007	3	3
LUNG_NSCLC_LUAD	MAML3 →	+0.935	+0.897	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF721 by Regulation of relaxation of cardiac muscle activity — BLOOD_Myeloma

Explore this box plot interactively →